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Vaccination: Vaccines
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Total 216 results found since Jan 2013.
Emerging threat of antimicrobial resistance in Neisseria gonorrhoeae: pathogenesis, treatment challenges, and potential for vaccine development
Arch Microbiol. 2023 Sep 9;205(10):330. doi: 10.1007/s00203-023-03663-0.ABSTRACTThe continuous rise of antimicrobial resistance (AMR) is a serious concern as it endangers the effectiveness of healthcare interventions that rely on antibiotics in the long run. The increasing resistance of Neisseria gonorrhoeae, the bacteria responsible for causing gonorrhea, to commonly used antimicrobial drugs, is a major concern. This has now become a critical global health crisis. In the coming years, there is a risk of a hidden epidemic caused by the emergence of gonococcal AMR. This will worsen the global situation. Infections caused by...
Source: Archives of Microbiology - September 9, 2023 Category: Microbiology Authors: Umairah Natasya Mohd Omeershffudin Suresh Kumar Source Type: research
United States' regulatory approved pharmacotherapies for nuclear reactor explosions and anthrax-associated bioterrorism
Expert Opin Drug Saf. 2023 Aug 18:1-6. doi: 10.1080/14740338.2023.2245748. Online ahead of print.ABSTRACTINTRODUCTION: Nuclear reactor incidents and bioterrorism outbreaks are concerning public health disasters. Little is known about US Food and Drug Administration (FDA)-approved agents that can mitigate consequences of these events. We review FDA data supporting regulatory approvals of these agents.AREAS COVERED: We reviewed pharmaceutical products approved to treat Hematopoietic Acute Radiation Syndrome (H-ARS) and to treat or prevent pulmonary infections following Bacillus anthracis (anthrax) exposure. Four drugs were a...
Source: Expert Opinion on Drug Safety - August 18, 2023 Category: Drugs & Pharmacology Authors: Charles L Bennett Peter Georgantopoulos Robert Peter Gale Kevin Knopf William J Hrushesky Chadi Nabhan James O Armitage Source Type: research
Spread of multidrug resistance in non-PCV13/PCV20 serotypes of Streptococcus pneumoniae: A cross-sectional study ten years after the introduction of pneumococcal conjugate vaccine in Japan
J Microbiol Immunol Infect. 2023 Jul 20:S1684-1182(23)00123-8. doi: 10.1016/j.jmii.2023.07.004. Online ahead of print.ABSTRACTTen years after the introduction of the pneumococcal conjugate vaccine (PCV) in Japan, the prevalence rates of non-PCV13 and non-PCV20 serotypes among pediatric pneumococcal isolates were 94.0% and 73.7%, respectively. The predominant non-PCV13/PCV20 serotypes (15A, 35B, and 23A) were mostly multidrug-resistant (≥80.5%), exhibiting non-susceptibility to penicillin.PMID:37517964 | DOI:10.1016/j.jmii.2023.07.004
Source: Journal of Microbiology, Immunology, and Infection - July 30, 2023 Category: Microbiology Authors: Mitsuyo Kawaguchiya Noriko Urushibara Meiji Soe Aung Nobuhide Ohashi Rika Takamatsu Sho Tsutida Masahiko Ito Nobumichi Kobayashi Source Type: research
Pneumococcal carriage, serotype distribution, and antimicrobial susceptibility in Papua New Guinean children vaccinated with PCV10 or PCV13 in a head-to-head trial
CONCLUSION: Even after PCV10 or PCV13 vaccination, children living in a high-risk setting such as PNG continue to experience high levels of pneumococcal colonization, including carriage of highly antimicrobial-resistant PCV serotypes. The study is registered with ClinicalTrials.gov (CTN NCT01619462).PMID:37479616 | DOI:10.1016/j.vaccine.2023.07.026
Source: Vaccine - July 21, 2023 Category: Allergy & Immunology Authors: Tilda Orami Celestine Aho Rebecca L Ford William S Pomat Andrew Greenhill Lea-Ann Kirkham Geraldine Masiria Birunu Nivio Kathryn J Britton Peter Jacoby Peter C Richmond Anita H J van den Biggelaar Deborah Lehmann Source Type: research
Serotypes and antimicrobial resistance of < em > Streptococcus pneumoniae < /em > in children under 5 years of age pre- and post-pneumococcal conjugate vaccine introduction in Paraguay
Conclusion. A change in the circulating serotypes and antimicrobial resistance to certain antibiotics was observed. Non-vaccine serotype circulation and multidrug resistance may compromise the success of the conjugate vaccines.PMID:37289483 | DOI:10.1099/jmm.0.001700
Source: Journal of Medical Microbiology - June 8, 2023 Category: Microbiology Authors: Mar ía Eugenia León Margarita Samudio An íbal Kawabata Minako Nagai Liliana Rojas Noem í Zárate Juan Irala Myrian Leguizam ón Gloria G ómez Juana Ortellado Raquel Blasco Rossana Franco Gustavo Chamorro Source Type: research
Pneumococcal serotypes and antibiotic resistance in healthy carriage children after introduction of PCV13 in Lima, Peru
CONCLUSION: The introduction of PCV13 in the immunization program in Peru has decreased the pneumococcal nasopharyngeal carriage and the frequency of PCV13 serotypes; however, there has been an increase in non-PCV13 serotypes and antimicrobial resistance.PMID:37270366 | DOI:10.1016/j.vaccine.2023.05.042
Source: Vaccine - June 3, 2023 Category: Allergy & Immunology Authors: Brayan E Gonzales Erik H Mercado Franco Castillo-Tokumori Andrea E Montero Alessandra Luna-Muschi Madhelli Marcelo-Ragas Francisco Campos Eduardo Chaparro Olguita Del Águila Mar ía E Castillo Andr és Saenz Isabel Reyes Roger Hernandez Theresa J Ochoa Source Type: research
Prevalence, capsular types, antimicrobial resistance and risk factors associated with pneumococcal carriage among children after long-term 10-valent pneumococcal conjugate vaccine use in Brazil
CONCLUSIONS: Long-term universal childhood use of PCV10 has nearly eliminated carriage with PCV10 serotypes, but the high frequency of MDR isolates, especially associated with serotype 6C/D, remains a concern. Replacing PCV10 with PCV13 should reduce the proportion of ERY-R isolates and PNSP by at least 14% and 18%, respectively.PMID:37061371 | DOI:10.1016/j.vaccine.2023.04.023
Source: Vaccine - April 15, 2023 Category: Allergy & Immunology Authors: Let ícia B D P Fortuna Filipe M Miranda Isa M F Antunes Amanda B Silva Amanda S Cabral Ítalo M Dolores Nayara T Cardoso-Marques L úcia M Teixeira Felipe P G Neves Source Type: research
